On August 26, 1961, Wing married Gerald "Jerry" Slick, an aspiring filmmaker, and after the couple briefly moved away from San Francisco, Grace Slick worked as a model at an I. Slick also started composing music, including a contribution to a short film by Jerry Slick.In August 1965, Slick read an article in the San Francisco Chronicle about the newly formed Jefferson Airplane.During a 1998 interview with VH1 on a Behind the Music documentary featuring Jefferson Airplane, Slick, who was never shy about the idea of getting old, said that the main reason she retired from the music business was, "All rock-and-rollers over the age of 50 look stupid and should retire." In a 2007 interview, she repeated her belief that, "You can do jazz, classical, blues, opera, country until you're 150, but rap and rock and roll are really a way for young people to get that anger out", and, "It's silly to perform a song that has no relevance to the present or expresses feelings you no longer have." Despite her retirement, Slick has appeared twice with Kantner's revamped version of Jefferson Starship; the first came in 1995 when the band played at Los Angeles's House of Blues, as documented on the live album Deep Space/Virgin Sky.
Although Slick was an equal contributor to the Great Society's original material, Darby Slick pushed the band toward becoming a raga-influenced psychedelic act.
In 1989, Slick and her former Jefferson Airplane band members reformed the group, released a reunion album, and made a successful tour.
Following the Jefferson Airplane reunion, Slick retired from the music business.
Jefferson Airplane became one of the most popular bands in the country and earned Slick a position as one of the most prominent female rock musicians of her time.
In 1968, Slick performed "Crown of Creation" on The Smothers Brothers Comedy Hour in blackface and ended the performance with a Black Panther fist.
She then removed the burqa to reveal a covering bearing an American flag and the words "Fuck Fear".